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动脉硬化与血栓均是在血管内皮细胞损伤的基础上发生的,血小板在损伤部位粘着、凝集,在血栓形成初期具有重要作用。对动脉硬化形成,血小板也起着重要作用,动脉硬化处内皮易脱落,在脱落处血小板粘着、凝集而成血栓,血栓形成进而使动脉硬化发展,成为心肌梗塞及脑栓塞等合并症的原因。以下试述血小板在动脉硬化中的作用以及冠心病抗血小板疗法概况。血小板在血栓形成中的作用因为血管内皮对血栓形成有种种防护机能血小板不粘连在正常内皮细胞上。各种原因使血管内皮细胞受损伤,内皮下结缔组织直接暴露于血流中,血小板粘着于该处,进而发生图1所示的一连串反应。
Arteriosclerosis and thrombosis are both based on the injury of vascular endothelial cells, platelets in the injury site adhesion, agglutination, in the early stages of thrombosis has an important role. The formation of atherosclerosis, also plays an important role in platelets, atherosclerosis endothelium is easy to fall off in the platelet adhesion, agglutination and thrombosis, thrombosis and thus the development of atherosclerosis, myocardial infarction and cerebral embolism and other complications. The following describes the role of platelets in atherosclerosis and anti-platelet therapy of coronary heart disease profile. Role of Platelets in Thrombosis Because of the protective function of the vascular endothelium on thrombosis, platelets do not adhere to normal endothelial cells. Vascular endothelial cells are damaged for a variety of reasons, and the subendothelial connective tissue is directly exposed to the bloodstream where the platelets stick and a series of reactions shown in Figure 1 occur.