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目的 :探讨头孢三嗪预防结直肠手术后感染的药代动力学依据。方法 :选择 12例结直肠癌患者 ,在麻醉诱导期单剂量静脉滴注头孢三嗪 2 g,给药后在 0 .5 h和 3 h分别取动脉血、腹部脂肪和腹直肌适量 ,并取结肠和肿瘤组织标本 ,用微生物法测定药物浓度。结果 :不同时间各部位药物浓度 :动脉血分别为 (2 30 .6 7± 36 .6 9)μg/ m L和 (132 .72± 18.84)μg/ m L ;腹壁脂肪分别为 (13.80± 3.5 8)μg/ g和 (7.87± 4.77)μg/ g;腹直肌分别为 (10 .6 8± 5 .0 1)μg/ g和 (7.14± 3.86 )μg/ g;结肠和肿瘤分别为 (2 9.0 9± 6 .78)μg/ g和 (2 2 .6 3± 11.0 8)μg/ g。结论 :麻醉诱导期单剂量静脉滴注头孢三嗪 2 g,在手术期间可提供有效的血液和组织药物浓度。
Objective: To investigate the pharmacokinetic basis of ceftriaxime in the prevention of colorectal surgery infection. Methods: A total of 12 patients with colorectal cancer were selected. Intravenous infusion of cefotaxime (2 g) was given during the induction period of anesthesia. The amount of arterial blood, abdominal fat and rectus abdominis were taken at 0. 5 h and 3 h Colon and tumor tissue samples were taken and the drug concentration was determined by the microbiological method. Results: The concentrations of arterial blood in different parts at different time points were (2.30.67 ± 36.69) μg / m L and (132.72 ± 18.84) μg / m L, respectively; the abdominal fat were (13.80 ± 3.5 (7.86 ± 4.77) μg / g and rectus abdominis were (10.68 ± 5.01) μg / g and (7.14 ± 3.86) μg / g, respectively; 2 9.0 9 ± 6 .78) μg / g and (22.3 ± 11.0 8) μg / g. CONCLUSION: A single dose of cefotaxime 2 g at the induction phase of anesthesia can provide effective blood and tissue drug concentration during the operation.