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红系生成素是一种调节红系祖细胞生长的激素。其血清浓度随着血氧含量的变化而发生相应的改变,以维持机体在低氧或高氧环境中的正常的生理功能。但当它的血浓度过高或过低时,会引起红细胞增多或红细胞生成不足。近年来,对它的研究和探讨取得了一定的成果,尤其是建立了准确、迅速的测定其血浓度的方法以及基因重组生产红系生成素。本文从其生化特点、产生机理、作用机制、测定方法、临床意义五个方面对其进行讨论。 1906年巴黎大学医学教授Carnot和Déflandae首次提出红系造血受激素调控学说。他们认为血液中存在一种刺激红系造血的体液因子,以后许多实验均证实这种因子的存在一红系生成素(Erythropoietin,简称Epo)。
Erythropoiesis is a hormone that regulates the growth of erythroid progenitor cells. The serum concentration changes with the changes in blood oxygen corresponding changes in order to maintain the body’s normal physiological function in hypoxia or hyperoxia environment. However, when its blood concentration is too high or too low, it can cause red blood cells or erythropoiesis. In recent years, some achievements have been made in its research and exploration, especially the establishment of an accurate and rapid method for the determination of its blood concentration and the production of erythropoietin by gene recombination. This article discusses its biochemical characteristics, mechanism of production, mechanism of action, determination method and clinical significance. 1906 University of Paris professor of medicine Carnot and Déflandae first proposed hematopoietic regulation of hormones. They think there is a kind of humoral factor that stimulates erythrocyte hematopoiesis in the blood. Many experiments later confirmed the existence of this factor, such as Erythropoietin (Epo).