提出自身免疫性肝炎(以下简称自免肝炎)这一概念的 Mackay 又倡导出一个假设:以病毒、药物或营养障碍所致肝脏损伤为契机可引起以自身肝脏为作用靶的免疫反应,并导致肝脏损伤的持续进展。Esteban(1989)首先报告自免肝炎的 C100抗体检出率高达44.1%。后来发现,自免肝炎也可检出 HCV·GOR 阳性,因而引发了这方面的研究兴致。 Mackay, who put forward the concept of autoimmune hepatitis, has also advocated the hypothesis that liver damage caused by viruses, drugs or nutritional disorders can trigger an immune response that targets the liver itself, leading to Continuous progression of liver damage. Esteban (1989) first reported a detectable rate of C100 antibody of 44.1% with self-hepatitis. It was later found that immunodeficiency hepatitis can also be detected HCV · GOR-positive, thus triggering the research interest in this area.