论文部分内容阅读
磷霉素(Fosfomycin)系1968年由Hendlin等研制成的广谱抗生素,其结构式很简单,与磷酸烯醇丙酮酸盐(Phosphoenolpyruvate)相似,作用于细菌壁合成的早期,为代谢拮抗剂。其半衰期长,因此1日给药2～3次能得到疗效。造血系统恶性肿瘤由于用强力的化学疗法,可引起明显的骨髓抑制,特别在粒细胞明显减少时,易合并各种重症感染。本文报道用大剂量磷霉素治疗合并各种感染的血液病的疗效观察。对象:1981年3月～1982年2月住院治
Fosfomycin is a broad-spectrum antibiotic developed by Hendlin et al. In 1968. Its structural formula is very simple and similar to phosphoenolpyruvate and acts as an early-stage metabolic antagonist in the early stage of bacterial wall synthesis. Its long half-life, so on the 1st administration of 2 to 3 times to be effective. Hematopoietic malignancies due to strong chemotherapy can cause significant myelosuppression, especially in significantly reduced granulocytes, easy to merge a variety of severe infections. This article reports the use of high doses of fosfomycin in the treatment of various infectious hematological malignancies observed. Object: March 1981 ~ February 1982 hospitalized