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目的观察泮托拉唑等四联法治疗胃溃疡的临床疗效。方法将胃溃疡患者206例随机分为研究组和对照组各103例。研究组患者采用四联法进行治疗,对照组采用三联法进行治疗。观察2组临床疗效、溃疡愈合情况、Hp根除率、溃疡复发率、治疗费用及不良反应发生情况。结果研究组总有效率为91.3%明显高于对照组的77.7%,差异有统计学意义(χ2=7.254,P<0.01)。2组患者溃疡愈合均以S2期为主,其中研究组S2获得率及溃疡愈合率明显高于对照组,差异均有统计学意义(χ2=21.812,P<0.01)。研究组Hp根除率显著高于对照组、胃溃疡复发率低于对照组,治疗费用少于对照组,不良反应总发生率明显低于对照组,差异有统计学意义(χ2=10.971,P<0.01)。结论泮托拉唑等组成的四联法治疗胃溃疡可发挥协同增效作用,有效抑制胃酸分泌,根除Hp感染,提高溃疡治愈率,降低复发率,且不良反应较少、安全性较高,具有重要临床价值。
Objective To observe the clinical efficacy of pantoprazole and other quadruple therapy in the treatment of gastric ulcer. Methods 206 cases of gastric ulcer patients were randomly divided into study group and control group of 103 cases. Patients in the study group were treated with quadruple-therapy, while those in the control group were treated with triple therapy. The clinical curative effect, ulcer healing, Hp eradication rate, ulcer recurrence rate, treatment cost and adverse reactions were observed. Results The total effective rate was 91.3% in the study group, which was significantly higher than that in the control group (77.7%) (χ2 = 7.254, P <0.01). The healing of ulcer in both groups was mainly in S2 stage. The rate of S2 recovery and the healing rate of ulcer in study group were significantly higher than those in control group (χ2 = 21.812, P <0.01). The study group Hp eradication rate was significantly higher than the control group, gastric ulcer recurrence rate was lower than the control group, treatment costs less than the control group, the overall incidence of adverse reactions was significantly lower than the control group, the difference was statistically significant (χ2 = 10.971, P < 0.01). Conclusions The quadruple treatment with pantoprazole can effectively reduce gastric acid secretion, eliminate Hp infection, improve the cure rate of ulcer and reduce the recurrence rate with less side effects and higher safety. Has important clinical value.