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目的：观察 Ｉ Ｌ２在小鼠抗弓形虫机理中的作用。方法：应用３ Ｈ尿嘧啶（３ Ｈ Ｕ）特异性标记弓形虫在小鼠腹腔巨噬细胞（ Ｍ ｏｕｓｅ ｐｅｒｉｔｏｎｅａｌｍ ａｃｒｏｐｈａｇｅ， Ｍ Ｐ Ｍ ）内的增殖实验及１２５ Ⅰ尿嘧啶核苷（１２５Ⅰ Ｕｄ Ｒ）标记的细胞毒实验，观察 Ｉ Ｌ２的抗弓形虫作用。结果： Ｉ Ｌ２对 Ｍ Ｐ Ｍ 的抗弓形虫作用及对 Ｉ Ｆ Ｎγ诱导的 Ｍ Ｐ Ｍ 抗弓形虫作用无明显影响；正常小鼠 Ｎ Ｋ 细胞杀伤弓形虫感染靶细胞的能力，显著低于杀伤肿瘤细胞的能力（ Ｐ＜ ０００１）；而经 Ｉ Ｌ２诱导的 Ｌ Ａ Ｋ 细胞杀伤自身感染弓形虫靶细 胞的能力， 明显高于 Ｎ Ｋ 细胞（ Ｐ＜ ０００１）， 并与 Ｌ Ａ Ｋ 杀伤肿瘤细胞的能力无明显差别（ Ｐ＞ ００５）。结论：提示 Ｉ Ｌ２体内应用提高弓形虫小鼠的生存能力的机理可能与提高体内 Ｌ Ａ Ｋ 细胞杀伤自身感染弓形虫细胞的能力有关。
Objective: To observe the role of IL-2 in anti-Toxoplasma mechanism in mice. Methods: The proliferation of Toxoplasma gondii in mice peritoneal macrophages (M P M) was assayed by 3H-UU (3 H U) and the effect of 125 Ⅰ uridine Ud R) labeled cytotoxic test observed I L 2 anti-Toxoplasma role. Results: The anti-Toxoplasma activity of I L2 to M P M and the anti-Toxoplasma gondii M P M induced by I F Nγ were not significantly affected. The ability of normal mouse N K cells to kill Toxoplasma gondii infected target cells, (P <0001). However, the ability of IL-2-induced L K cells to kill Toxoplasma gondii target cells was significantly higher than that of N K cells (P <0001) ) And no significant difference (P> 0.05) with the ability of L A K to kill tumor cells. Conclusion: The mechanism of in vivo application of I L2 to improve the viability of Toxoplasma gondii Mice may be related to the ability of L K cells to kill Toxoplasma gondii in vivo.