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通过放射免疫法测定维、汉两族胃溃疡(GU)、十二指肠溃疡(DU)、胃癌(GC)患者血清胃泌素水平。结果显示,两族GU、DU、GC均存在一定的高胃泌素血症,与同族慢性浅表性胃炎(CSG)组比较有显著性差异(P<0.01);两族GC与同族GU比较有显著性差异(P<0.05),与DU比较有显著性差异(P<0.01),这有助于胃良、恶性病变的鉴别;维族GU发病年龄及血清胃泌素水平均显著高于同期汉族;维族胃底、贲门癌血清胃泌素水平显著高于汉族及同族胃窦癌(P<0.05)。高胃泌素血症可能是诱致胃癌的一个重要原因,也可能是维族高发胃底、贲门癌的重要因素。
Serum gastrin levels in patients with gastric ulcer (GU), duodenal ulcer (DU), and gastric cancer (GC) were measured by radioimmunoassay. The results showed that there were certain hypergastrinemia in GU, DU, and GC of the two families, which was significantly different from that in the chronic superficial gastritis (CSG) group of the same family (P<0.01); the two groups of GC were compared with the same family of GU. There was a significant difference (P<0.05), and there was a significant difference compared with DU (P<0.01), which was helpful for the differentiation of benign and malignant gastric lesions. Uighur GU onset age and serum gastrin levels were significantly higher than the same period. The serum level of gastrin in the Uygur and stomach cancers of the Uygur population was significantly higher than that of the Han and the same group (P<0.05). Hypergastrinemia may be an important cause of gastric cancer induction, and may also be an important factor in Uighur high stomach and cardiac cancer.