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甲硝唑-金霉素复合剂作外抗革兰氏阴性需氧菌的作用较林可霉素为弱,但抑制革兰氏阴性需氧菌的效果却优于林可霉素。该复合剂对革兰氏阳性厌氧菌的抑菌效果明显优于林可霉素和甲硝唑,表明对此类细菌有协同抗菌作用。甲硝唑-金霉素复合剂抗革兰氏阴性厌氧菌的作用亦较林可霉素为强。1:1、1:3和1:6(甲硝唑:金霉素,W/W)的复合剂中以1:3的抗菌效果最好。实验结果表明,甲硝唑-金霉素复合剂(1:3,W/W)可用于制备药膜,用于治疗口腔溃疡等疾病。
Metronidazole - chlortetracycline compound for external anti-gram-negative aerobic bacteria role than lincomycin is weak, but the effect of inhibiting Gram-negative aerobic bacteria is better than lincomycin. The antibacterial activity of the complex against Gram-positive anaerobic bacteria is obviously superior to that of lincomycin and metronidazole, indicating that the bacteria have a synergistic antibacterial effect. The effect of metronidazole - chlortetracycline complex against gram-negative anaerobes is also stronger than lincomycin. 1: 1, 1: 3 and 1: 6 (metronidazole: chlortetracycline, W / W) in the best antibacterial effect of 1: 3. Experimental results show that metronidazole - chlortetracycline compound (1: 3, W / W) can be used for the preparation of membrane for the treatment of diseases such as oral ulcers.