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提供化学毒物经皮吸收的资料,十分有利于发展生物接触限值的卫生标准和解释生物监测的结果。化学物经皮吸收的研究不仅是目前皮肤毒理学的热门课题,也是开展生物监测的一项基础工作。 1 化学物经皮吸收的途径与机理 1.1 皮肤对化学物的屏障作用正常皮肤对化学物的主要屏障部位在表皮的角质层。角质层由12～20层死亡的角质细胞构成,每个细胞长约30μm,宽约0.8μm,它们互相交叉、重叠,呈平板状。最外面的
The provision of information on percutaneous absorption of chemical toxins is very helpful for developing hygiene standards for biological exposure limits and for interpreting the results of biological monitoring. The study of transdermal absorption of chemicals is not only a hot topic in skin toxicology at present, but also a basic work of biological monitoring. 1 pathways and mechanisms of percutaneous absorption of chemicals 1.1 The barrier effect of the skin on chemicals Normal skin The main barrier of chemicals in the stratum corneum of the epidermis. The stratum corneum consists of 12 to 20 dead layers of keratinocytes, each about 30 μm long and about 0.8 μm wide. They cross each other, overlap, and are flat. The outermost