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急性胰腺炎患者大约60—75%可康复,25～40%会演变有威协的并发症,4—25%则会在急性发作期内死亡。病变的胰腺释放蛋白水解酶、脂肪酸,胰蛋白酶原、血管活性肽等毒性物质到血液或腹水中,导致血管通透性增加及组织的自溶坏死等病变。休克,心、肺、肾单个或多个脏器的机能衰竭是疾病前期的主要死因,后期死亡常和坏死区细菌繁殖、毒素释放及脓肿等感染性并发症有关。清除这些毒性物质和控制感染可以改善重症胰腺炎的预后。许多方法已被提出用于作为挽救生命的措施。腹腔灌洗治疗重症胰腺炎的价值是wall偶然发现的,他对三例并发肾衰的急性胰腺炎进行腹膜透析二例获救。此后,该法在临床上逐步得到推广应用。
Approximately 60-75% of patients with acute pancreatitis are able to recover, 25-40% will develop complications with NCD, and 4-25% will die during acute exacerbation. Lesions of the pancreas release of proteolytic enzymes, fatty acids, trypsinogen, vasoactive peptides and other toxic substances into the blood or ascites, leading to increased vascular permeability and tissue autolysis necrosis and other diseases. Shock, heart, lung, kidney failure of one or more organs is the leading cause of death, and late death often associated with infectious complications such as bacterial growth, toxin release and abscess in the necrotic area. Clearing these toxic substances and controlling infection can improve the prognosis of severe pancreatitis. Many methods have been proposed for use as life-saving measures. The value of peritoneal lavage for the treatment of severe pancreatitis was accidentally discovered on the wall. He was given two cases of peritoneal dialysis in three cases of acute pancreatitis complicated with renal failure. Since then, the law has been gradually applied in clinical practice.