在牙齿发育过程中,当牙冠发育完成后,上皮根鞘的形成启动了牙根发育,然而关于牙根发育启动的分子调控机制目前尚未明了。该文就近年来关于牙根发育启动的信号通路,主要包括Shh信号通路、TGF-β信号通路、Nfic家族、成纤维细胞生长因子家族以及Notch信号通路等的研究进展作一综述。 During the development of the tooth, the formation of the epithelial root sheath initiates the development of the root sheath when the development of the tooth crown is completed, however, the molecular regulation mechanism for the initiation of root development is not yet known. This review summarizes recent advances in the signaling pathway of root development, including the Shh signaling pathway, the TGF-β signaling pathway, the Nfic family, the fibroblast growth factor family, and the Notch signaling pathway.