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研究了人参茎叶皂甙（ＧＳＬ）对创伤小鼠活化Ｔ细胞内磷脂酰肌醇代谢的影响。结果显示，ＧＳＬ体内应用（５０ｍｇ·ｋｇ￣（－１）·ｄ￣（－１），伤后０─３ｄ）对创伤小鼠活化Ｔ细胞内三磷酸肌醇（ＩＰ＿３）、游离Ｃａ￣（２＋）、钙调素（ＣａＭ）、ＣａＭ依赖的蛋白激酶（ＣａＭ－Ｐｋ）、蛋白激酶Ｃ（ＰＫＣ）水平的降低具有明显的逆转效应，并可明显降低创伤小鼠血清、巨噬细胞、Ｔｓ细胞对各指标的抑制活性。ＧＳＬ（１．０─１００ｍｇ／Ｌ）在体外也可明显提高创伤小鼠活化Ｔ细胞内ＩＰ＿３、Ｃａ￣（２＋）、ＣａＭ、ＣａＭ－ＰＫ及ＰＫＣ水平。上述结果表明，ＧＳＬ可逆转创伤小鼠活化Ｔ细胞内磷脂酰肌醇代谢的降低。
The effect of ginseng stem and leaf saponin (GSL) on phosphatidylinositol metabolism in activated T cells of traumatic mice was studied. The results showed that in vivo application of GSL (50 mg · kg -1 · d -1, 0 ~ 3 d post injury), the activity of inositol 1,4,5-trisphosphate (IP_3) and free Ca ~ (2+) ), CaM, CaM-Pk and PKC significantly reduced the levels of serum, macrophage and Ts cells in traumatized mice Inhibitory activity on each index. GSL (1.0 ~ 100mg / L) also significantly increased the levels of IP_3, Ca ~ (2 +), CaM, CaM-PK and PKC in activated T cells of traumatized mice in vitro. The above results indicate that GSL can reverse the decrease of phosphatidylinositol metabolism in activated T cells of traumatic mice.