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腹腔注射或皮下注射本品128～250 mg/kg,对二甲苯、组织胺、醋酸等所致小白鼠皮肤或腹腔毛细血管通透性增高、蛋清所致大鼠足肿胀及巴豆油所致炎性渗出均有明显的抑制作用,但对肉芽组织增生无明显影响。由于去除肾上腺后其抗炎作用消失,本品也不能延长去肾上腺幼年大白鼠的生存时间,但可引起幼年小白鼠胸腺萎缩、明显降低大白鼠肾上腺中维生素C的含量,多次给药并可增加垂体前叶中ACTH的含量,因此说明本品不具有肾上腺皮质激素样作用,但能兴奋垂体——肾上腺皮质系统功能,这一作用是在于促进了垂体前叶ACTH的合成和释放。继以大白鼠肾上腺中维生素C含量降低为指标,分析了本品作用的部位,结果表明,动物去除垂体后,此作用消失,戊巴比妥钠麻醉,作用仍然存在,但在戊巴比妥钠麻醉的基础上,吗啡、地塞米松、氯丙嗪等均能完全阻断本品降低肾上腺中维生素C含量的作用,上述结果提示本品兴奋垂体——肾上腺皮质系统功能的作用部位可能在皮层下中枢。
Intraperitoneal injection or subcutaneous injection of this product 128 ~ 250 mg / kg, paracetamol, histamine, acetic acid and other mice caused by increased permeability of the skin or peritoneal capillary, egg white induced rat foot swelling and inflammation caused by croton oil Exudation were significantly inhibited, but no significant effect on granulation tissue proliferation. Due to its disappearance of anti-inflammatory effect after removal of the adrenal gland, this product can not prolong the survival time of adolescent rats to adrenal gland, but can cause thymus atrophy in young mice, significantly reduce the adrenal vitamin C content in rats, multiple administration and Increase the content of ACTH in the anterior pituitary, so that this product does not have the effect of adrenal cortex hormones, but can excited pituitary - adrenal system function, this role is to promote the anterior pituitary ACTH synthesis and release. Following the rat adrenal vitamin C content decreased as an indicator of the product of the role of the site, the results show that the removal of pituitary animals, this effect disappeared, pentobarbital sodium anesthesia, the role still exists, but in pentobarbital Sodium anesthesia on the basis of morphine, dexamethasone, chlorpromazine, etc. can completely block the product to reduce the role of vitamin C content in the adrenal gland, the above results suggest that this product excited pituitary - adrenal cortex system may function in the role of Subcortical center.