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研究川芎嗪的心肌保护及抗氧化作用机制。在心脏停跳液中加入川芎嗪后对离体兔心脏进行缺血再灌注 ,然后观察心肌线粒体内丙二醛 (MDA)含量、超氧化物岐化酶 (SOD)活性及心肌组织超微结构损伤程度。发现含有川芎嗪的停跳液组丙二醛 (MDA)含量显著降低 ,超氧化物岐化酶 (SOD)活性显著升高 ,观察心肌组织超微结构损伤程度发现较轻。因此 ,川芎嗪对缺血心肌具有良好的保护及抗氧化作用。
To study the myocardial protection and anti-oxidation mechanism of tetramethylpyrazine. After addition of tetramethylpyrazine in cardioplegia, isolated rabbit hearts were subjected to ischemia-reperfusion, and then the contents of malondialdehyde (MDA), superoxide dismutase (SOD) activity and myocardial ultrastructure were observed in myocardial mitochondria. degree of damage. The content of malondialdehyde (MDA) in the cardioplegia group containing tetramethylpyrazine was significantly reduced, and the activity of superoxide dismutase (SOD) was significantly increased. The ultrastructural damage of myocardial tissue was observed to be lighter. Therefore, tetramethylpyrazine has good protection and anti-oxidation effect on ischemic myocardium.