论文部分内容阅读
目的:探讨经鼻间歇正压通气联合猪肺磷脂注射液治疗新生儿呼吸窘迫综合征临床疗效及安全性的影响。方法:前瞻性研究于我院进行治疗的呼吸窘迫综合症患儿60例,根据电脑生成的随机数字表将所有患儿随机分为实验组与对照组,每组各30例,对照组患儿使用经鼻间歇正压通气进行治疗,实验组患儿在对照组的基础上联合猪肺磷脂注射液进行治疗。治疗结束后比较两组患儿动脉血氧分压(Pa O_2)、动脉血二氧化碳分压(Pa CO_2)、氧合指数及血样饱和度(Sa O_2)水平的变化,统计并记录两组患儿并发症的发病情况,并对两组患儿的临床疗效进行评价。结果:与治疗前相比,两组患儿Pa CO_2水平均降低,Pa O_2、Sa O_2水平及氧合指数均升高(P<0.05);与对照组相比,实验组患儿Pa CO_2水平较低,Pa O_2、Sa O_2水平及氧合指数较高(P<0.05);且与对照组相比,实验组的并发症发病率较低,临床总有效率较高(P<0.05)。结论:经鼻间歇正压通气联合猪肺磷脂注射液治疗新生儿呼吸窘迫综合征安全有效,值得在临床上推广应用。
Objective: To investigate the clinical efficacy and safety of nasal intermittent positive pressure ventilation combined with porcine pulmonary phospholipid injection in the treatment of neonatal respiratory distress syndrome. Methods: A prospective study of 60 children with respiratory distress syndrome treated in our hospital was conducted. All children were randomly divided into experimental group and control group according to random number table generated by computer. Each group had 30 cases and control group The use of nasal intermittent positive pressure ventilation for treatment, experimental group children in the control group based on the combination of pulmonary phlebitis injection for treatment. After treatment, the changes of Pa O 2, Pa CO 2, oxygenation index and Sa O 2 in the two groups were compared, and two groups of children The incidence of complications, and the clinical efficacy of two groups of children were evaluated. Results: Compared with those before treatment, both PaCO 2 levels, Pa O 2, Sa O 2 levels and oxygenation index (P <0.05) were significantly increased in both groups. Compared with the control group, Pa CO 2 level (P <0.05). Compared with the control group, the incidence of complication in the experimental group was lower and the total clinical effective rate was higher (P <0.05). Conclusion: Nasal intermittent positive pressure ventilation combined with pulmonary phlebitis injection in the treatment of neonatal respiratory distress syndrome is safe and effective, which is worth popularizing in clinic.