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Ｗｉｓｔａｒ大鼠４８只随机分三组，Ａｌｌｅｎ＇ｓ脊髓损伤（ＳＣＩ）模型２５０ｇ·ｃｍ致伤Ｔ_（１３）～Ｌ_１脊髓节段，腹腔注射三七总皂甙（ＰＮＳ），伤后３０ｍｉｎ时１００ｍｇ／ｋｇ，２ｈ及４ｈ各５０ｍｇ／ｋｇ；以二甲亚砜（ＤＭＳＯ）为抗氧自由基阳性对照药物，并设立空白对照。伤后１ｈ及４ｈ取伤区脊髓组织测定丙二醛（ＭＤＡ）及超氧化物歧化酶（ＳＯＤ），发现ＰＮＳ显著减少ＭＤＡ的生成，保护ＳＯＤ活力降低。组织形态学观察到灰质区出血坏死，髓鞘分离及线粒体水肿较轻。提示ＳＣＩ早期ＰＮＳ具有明显的抗氧自由基反应和减轻继发性损害的作用。
48 Wistar rats were randomly divided into 3 groups. Allen’s spinal cord injury (SCI) model 250g·cm injured the T_13~L_1 spinal cord segment and was intraperitoneally injected with Panax Notoginseng (PNS). At the time of 30 minutes after the injury, 100 mg/kg. Kg, 2h and 4h each 50mg/kg; Dimethyl sulfoxide (DMSO) as a positive control drug against oxygen free radicals, and set up a blank control. Malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in the spinal cord at 1h and 4h after injury. It was found that PNS significantly reduced the production of MDA and decreased the activity of SOD. Histomorphology observed hemorrhage and necrosis in gray matter areas, myelin separation, and mitochondrial edema were lighter. It is suggested that the early PNS of SCI has obvious anti-oxygen free radical reaction and the effect of reducing secondary damage.