论文部分内容阅读
目的:研究Beagle犬灌胃给予荷叶生物碱部位配伍何首乌二苯乙烯苷部位后荷叶碱的药动学特征,并与Beagle犬单独灌胃荷叶生物碱部位后荷叶碱的药动学参数进行对比,为荷叶制剂研制和临床应用提供实验依据。方法:Beagle犬灌胃给予荷叶生物碱部位0.15g/kg配伍何首乌二苯乙烯苷部位0.46g/kg后,定时取血,RPHPLC法测定血浆荷叶碱药物浓度,采用DAS软件计算药动学参数。结果:配伍何首乌二苯乙烯苷部位后,荷叶碱在Beagle犬体内药动学过程符合二室开放式模型;通过对配伍前后荷叶碱在Beagle犬体内的各药带动力学参数比较,结果表明,t1/2kα、t1/2α、Tmax和Cmax在两组中差异不大;配伍后荷叶碱的t1/2β(0.582h)小于单独灌胃荷叶生物碱部位后t1/2β(0.850h)。结论:配伍前后的药动学参数研究表明,配伍何首乌二苯乙烯苷部位后,不影响荷叶碱在Beagle犬体内的吸收、分布过程,但在一定程度上会加快荷叶碱在Beagle犬体内的消除。
OBJECTIVE: To study the pharmacokinetics of the nuciferine in Beagle dogs treated with intragastric administration of alkaloids in the lotus leaf and compatibility of the lotus root with alkaloids in the Beagle dogs. Parameters were compared for lotus leaf preparation and clinical application of experimental basis. Methods: Beagle dogs were intragastrically given Lotion alkaloids 0.15g / kg with Polygonum upnitoside 0.46g / kg, the timing of blood sampling, RPHPLC determination of plasma drug content of lotus root, using the DAS software to calculate the pharmacokinetics parameter. Results: The pharmacokinetics of lotus leaf in Beagle dogs was in accordance with the two-compartment open model after compatibility with the site of stilbene glycoside. By comparing the kinetic parameters of each drug in the Beagle dogs before and after compatibility, the results showed that , t1 / 2kα, t1 / 2α, Tmax and Cmax were not significantly different between the two groups. The t1 / 2β (0.582h) of lotus leaf was less than t1 / 2β (0.850h) . Conclusion: The study of pharmacokinetic parameters before and after compatibility shows that the compatibility and the absorption process of lotus root in Beagle dogs do not affect the absorption and distribution of lotus root in Beagle dogs, but to a certain extent, Elimination.