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目的探讨CT在评价肝癌冷冻治疗疗效中的作用。方法20只新西兰大白兔随机分为对照组(n=10)和氩氦冷冻组(n=10),在肝脏接种VX2肿瘤后第14天分别给予假手术和氩氦冷冻,干预后第7、14、28、42天行CT平扫和双期增强检查,观察2组肿瘤体积和CT动态表现,并比较2组肝内转移有无差异。结果干预后第42天,氩氦冷冻组肿瘤体积(387.68±291.30)mm3明显小于对照组(50872.29±7199.62)mm3。对照组肿瘤呈不规则混杂强化,氩氦冷冻组冷冻区边缘早期呈薄壁环形强化,随后逐渐减弱消失,而中心无强化。氩氦冷冻组肝内转移率(30%)明显低于对照组(100%)。结论兔VX2肝癌氩氦冷冻后CT表现为肿瘤彻底损毁,同时肝内转移减少。CT可作为评价肝癌冷冻治疗疗效的有效手段。
Objective To explore the role of CT in evaluating the curative effect of liver cancer cryotherapy. Methods Twenty New Zealand white rabbits were randomly divided into control group (n = 10) and argon-helium cryo-freezing group (n = 10). After the liver was inoculated with VX2 tumor, sham operation and argon- 14,28,42 day CT plain scan and two-phase enhanced examination to observe the two groups of tumor volume and CT dynamic performance, and compared two groups of liver metastasis with or without difference. Results On the 42nd day after intervention, the tumor volume in the argon-helium cryotherapy group (387.68 ± 291.30) mm3 was significantly lower than that in the control group (50872.29 ± 7199.62) mm3. The tumor in the control group showed an irregular hybrid enhancement. The edge of the frozen area of the argon-helium cryotherapy group was thin-walled annularly enhanced early, then gradually weakened and disappeared, while the center did not strengthen. The rate of intrahepatic metastasis (30%) in argon-helium cryogenic group was significantly lower than that in control group (100%). Conclusion The CT appearance of rabbit VX2 liver cancer after argon-helium cryoablation was completely destroyed by the tumor, meanwhile the liver metastasis decreased. CT can be used as an effective evaluation of the efficacy of liver cancer cryotherapy.