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目的探讨阿奇霉素转换治疗支原体肺炎的可行性及疗效。方法选择2007年1月-2008年12月本院儿科住院支原体肺炎患儿115例。随机分组为静脉给药组(V组)和转换治疗组(S组)。V组按阿奇霉素使用方法静脉用药,S组按阿奇霉素使用方法静脉用药3 d后改为口服。观察二组患儿体温、咳嗽、肺部啰音变化和不良反应发生情况,并于给药第15天复查胸片。结果 V组治愈50例,S组治愈32例,二组治愈率比较差异无统计学意义(χ2=0.114,P>0.05)。二组退热时间[(2.81±0.77)dvs(2.78±0.80)d]、肺部啰音消失时间[(4.98±1.59)dvs(4.72±1.05)d]、咳嗽明显减轻时间[(7.51±1.87)dvs(7.38±1.91)d]、胸片阴影消失例数(50例vs32例)比较差异均无统计学意义(Pa>0.05);二组胃肠道反应和皮疹发生率比较差异均无统计学意义(χ2=0.014、0.190,Pa>0.05),但局部静脉疼痛发生例数比较存在明显差异(χ2=4.650,P<0.05)。结论转换治疗和静脉应用阿奇霉素疗效相同,而局部静脉疼痛不良反应明显降低。
Objective To investigate the feasibility and efficacy of azithromycin in the treatment of mycoplasma pneumonia. Methods From January 2007 to December 2008, 115 children with mycoplasmal pneumonia were admitted to our hospital. Randomly divided into intravenous group (V group) and conversion treatment group (S group). V group by azithromycin intravenous medication, S group by azithromycin intravenous medication 3 d after oral administration. The changes of body temperature, cough, changes of pulmonary rales and adverse reactions in the two groups were observed. The chest radiographs were reviewed on the 15th day of administration. Results In group V, 50 cases were cured and 32 cases in group S were cured. There was no significant difference in cure rate between the two groups (χ2 = 0.114, P> 0.05). (2.81 ± 0.77) dvs (2.78 ± 0.80) d], the disappearance time of pulmonary rales [(4.98 ± 1.59) d vs 4.72 ± 1.05 d], and the time to relieve cough ([7.51 ± 1.87 ) dvs (7.38 ± 1.91) d], the disappearance of chest shadow (50 cases vs. 32 cases) showed no significant difference (P> 0.05). There was no statistical difference in the incidence of gastrointestinal reactions and rash between the two groups (Χ2 = 0.014,0.190, Pa> 0.05), but there were significant differences in the number of local venous pain (χ2 = 4.650, P <0.05). Conclusion Conversion therapy and intravenous azithromycin have the same effect, while the local venous pain adverse reaction was significantly reduced.