目的探讨24h脑电(AEEG)监测对难治性癫痫的临床意义。方法对96例难治性癫痫患者进行连续24hAEEG监测。结果AEEG痫波阳性率为64.29%,与常规EEG的28.21%相比较,差异有极显著意义(P<0.001)。且痫样放电与睡眠密切相关。96例患者中捕获41例(42.71%)临床发作,其中31例确诊为癫痫发作;2例癫痫合并假性发作;3例假性发作;3例睡眠呼吸暂停综合征(SAS);2例癫痫合并SAS。结论24hAEEG携带方便,监测期间自然睡眠不受环境改变的影响,显著提高了临床癫痫发作和痫样放电阳性率,还可作为难治性原因之一SAS的筛查检测,有助于难治性癫痫的诊断和鉴别诊断。 Objective To investigate the clinical significance of 24h EGG monitoring on refractory epilepsy. Methods 96 consecutive patients with refractory epilepsy were monitored by 24-h AEEG. Results The positive rate of AEEG was 64.29%, which was significantly different from that of 28.21% of the normal EEG (P <0.001). And epileptiform discharge and sleep are closely related. Seventy-one patients (42.71%) had clinical seizures in 96 patients, of whom 31 were diagnosed as seizures; 2 were epilepsy with pseudo-episodes; 3 were pseudo-episodes; 3 were with sleep apnea syndrome (SAS); 2 were epilepsy SAS. Conclusions 24hAEEG is easy to carry and spontaneous sleep during the monitoring period is not affected by environmental changes, which significantly increases the positive rate of clinical seizures and epileptiform discharges. It can also be used as a screening test for SAS, which is one of the reasons of refractory. Epilepsy diagnosis and differential diagnosis.