目的 :侵及浆膜的胃癌腹膜种植复发是外科治疗失败的重要因素之一。本文探讨术后腹腔内化疗在防治腹膜复发的作用。方法 :对我院 3年间行手术治疗的胃癌 40 4例中癌肿侵及浆膜又无种植灶及远处转移的 41例术后行腹腔内化疗 (治疗组 )其临床效果与同期未行腹腔内化疗 (对照组 )进行对照观察。结果 :治疗组一、三、五年生存率为 89% ,73 % ,5 7% ,对照组为 83 % ,6 1%和 39% ,五年存活率P <0 0 5。结论 :腹腔内化疗因其腹腔内药物浓度高 ,剂量大 ,毒副作用小 ,对侵及浆膜的胃癌有着防止复发的积极作用 Objective: Invasion and serosal invasion of the peritoneum of gastric cancer recurrence is an important factor in the failure of surgical treatment. This article discusses postoperative intraperitoneal chemotherapy in the prevention and treatment of retroperitoneal recurrence. Methods: Forty-four cases of gastric cancer who underwent surgical treatment within 3 years in our hospital were treated with intraperitoneal chemotherapy (41 cases) with no invasion of the tumor and distant metastasis. The clinical effect of the treatment was not observed in the same period Controlled intraperitoneal chemotherapy (control group). Results: The 1-, 3- and 5-year survival rates were 89%, 73% and 57% in the treatment group, 83%, 61% and 39% in the control group, respectively. The five-year survival rate was P 0 05. CONCLUSION: Intraperitoneal chemotherapy has the positive effect of preventing recurrence of gastric cancer invading the serosa due to its high concentration of intraperitoneal drugs, large dosage and low toxic and side effects