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目的：探讨长托宁联合昂丹司琼在预防全麻下妇科腹腔镜手术术后恶心呕吐（PONV）的临床效果。方法选取90例ASAⅠ～Ⅱ级,择期进行妇科腹腔镜手术的患者，随机分成A、B、C三组。A组为对照组、B组为昂丹司琼组、C组为长托宁联合昂丹司琼组,观察术后24h内患者恶心呕吐的发生几率及程度。结果 C组及B组术后24h内PONV的发生率和程度较A组明显减轻,P<0.05，差别有统计学意义；C组较B组术后24h内PONV的发生率和程度更低,P<0.05，差别有统计学意义。结论长托宁联合昂丹司琼预防PONV有协同作用,可降低PONV的发生率及严重程度。“,”Subject:This study aimed to investigate the clinical effect of the combination of penehyclidine hydrochloride and ondansetron on prevention of postoperative nausea and vomiting (PONV)after gynecological laparoscopic surgery under general anesthesia.Methods:90 ASA I-I patients undergoing elective laparoscopic operations were divided into three groups, and normal saline(group A),ondansetron(group B) or penehyclidine hydrochloride combined with ondansetron (group C) were given randomly.The incidence and severity of PONV were recorded 24 hours after surgery.Results:The incidences and severity of PONV in group A were higher than group A and group B significantly (P < 0.05). And there were significant differences in the incidence and severity of PONV in group C and group B (P<0.05).Conclusion: The synergistic effect of penehyclidine hydrochloride combined with ondansetron was effective in reducing the incidence and severity of PONV.