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本实验观察大鼠急性庆大霉素和升汞中毒性肾损伤时肾组织与过氧化脂质（ＬＰＯ）有关指标的变化。结果表明，庆大霉素（６０ｍｇ／ｋｇｉｐｑｄ）中毒７２ｈ和升汞（５ｍｇ／ｋｇ．ｉｍ）中毒２４ｈ后肾功能受损，肾系数增大。肾组织中的丙二醛（ＭＤＡ）游离氨基酸，（ＦＦＡ）含量增高，黄嘌呤氧化酶（ＸＯ）活性增强，这些指标可能是庆大霉素和升汞中毒性肾损伤的重要介导因素。黄嘌呤－ＸＯ系统激活可能是导致氧自由基（ＯＦＲ）产生增多、ＬＰＯ增强的重要机制。
This experiment observed acute gentamicin and mercury-induced toxic renal injury with changes of lipid peroxide (LPO) related indicators. The results showed that gentamicin (60mg / kg ipqd) poisoning 72h and mercuric chloride (5mg / kg.im) poisoning after 24h renal function, renal coefficient increased. The contents of free amino acid (FFA) and xanthine oxidase (XO) in malondialdehyde (MDA) in renal tissue were increased, which might be the important mediators of gentamicin and mercury-induced toxic renal injury. Xanthine-XO system activation may lead to increased oxygen free radicals (OFR), LPO enhanced an important mechanism.