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目的 探讨增殖细胞核抗原（ＰＣＮＡ）和层粘连蛋白（ＬＮ）单克隆抗体免疫组化染色在口腔癌前病变的表达及意义。方法用 ＰＣＮＡ和ＬＮ单克隆抗体ＡＢＣ法行免疫组化染色。结果 ＰＣＮＡ免疫组化染色证明，白斑随病变程度加重，ＰＣＮＡ染色强度及分级逐渐增强。扁平苔藓伴异常增生与异常增生性白斑有相似染色强度，也为癌前病变。结论ＬＮ能提示异常增生性白斑癌变可能性及恶性肿瘤的侵袭性和恶性程度。ＰＣＮＡ和ＬＮ是诊断癌前病变恶变的有价值的方法之一。
Objective To investigate the expression and significance of immunohistochemical staining of proliferating cell nuclear antigen (PCNA) and laminin (LN) monoclonal antibody in oral precancerous lesions. Methods PCNA and LN monoclonal antibody ABC method immunohistochemical staining. Results PCNA immunohistochemical staining showed that leukoplakia with the severity of the disease, PCNA staining intensity and grading gradually increased. Lichen planus with abnormal proliferation and dysplasia of white spots have similar staining intensity, but also precancerous lesions. Conclusion LN can prompt the possibility of malignant transformation of dysplasia and the aggressiveness and malignancy of malignant tumors. PCNA and LN are one of the valuable methods to diagnose malignant transformation of precancerous lesions.