【摘 要】
：
The pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a high number of deaths in the world.To combat it,it is necessary to develop a better understanding of how the virus infects host cells.Infection normally starts w
【机 构】
：
NHC Key Laboratory of Systems Biology of Pathogens,Chinese Academy of Medical Sciences and Peking Un
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The pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a high number of deaths in the world.To combat it,it is necessary to develop a better understanding of how the virus infects host cells.Infection normally starts with the attachment of the virus to cell-surface gly-cans like heparan sulfate (HS) and sialic acid-containing glycolipids/glycoproteins.In this study,we examined and compared the binding of the subunits and spike (S) proteins of SARS-CoV-2,SARS-CoV,and Middle East respiratory disease (MERS)-CoV to these glycans.Our results revealed that the S proteins and subunits can bind to HS in a sulfation-dependent manner and no binding with sialic acid residues was detected.Overall,this work suggests that HS binding may be a general mechanism for the attach-ment of these coronaviruses to host cells,and supports the potential importance of HS in infection and in the development of antiviral agents against these viruses.
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