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目的:观察清热排毒合剂解热、抑菌及抗炎作用。方法:解热实验采用大鼠2,4-二硝基苯酚发热模型;抑菌实验采用体外二倍稀释法;抗炎实验采用小鼠耳廓二甲苯致炎模型。结果:清热排毒合剂能抑制2,4-二硝基苯酚致大鼠体温升高,体外对金黄色葡萄球菌、辐氏志贺氏菌、甲型链球菌、乙型溶血链球菌、大肠埃希菌等均有不同程度的抑制作用,能明显抑制二甲苯所致小鼠耳肿胀。结论:清热排毒合剂具有解热、抑菌及抗炎作用。
Objective: To observe the antipyretic, antibacterial and anti-inflammatory effects of Qingrejiedu Mixture. Methods: The rat model of 2,4-dinitrophenol fever was used in the antipyretic experiment, the bacteriostasis method was double-diluted in vitro, and the mouse auricle xylene-induced inflammation model was used in the anti-inflammatory experiment. Results: JTD can inhibit 2,4-dinitrophenol-induced rat body temperature increase in vitro against Staphylococcus aureus, Shigella flexneri, streptococcus albides, hemolytic streptococcus B, Escherichia coli Bacteria, etc. have different degrees of inhibition, can significantly inhibit xylene-induced mouse ear swelling. Conclusion: Qingrejiedu mixture has antipyretic, antimicrobial and anti-inflammatory effects.