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目的研究一种制备壳状中空微囊的新方法,并考察致孔剂对微囊释药行为的影响。方法在囊材聚乙烯醇(PVA)中加入致孔剂聚乙二醇(PEG),采用悬浮界面交联法制备氟尿嘧啶(5-flurourac il,5-FU)壳状中空微囊,通过考察其粒径、包封率、载药量优化处方工艺。通过考察体外释药性能,研究致孔剂对微囊释药行为的影响。结果该新工艺制备的微囊为壳状中空结构,其平均粒径为22μm,载药量、包封率分别为15.6%、84.8%。加入致孔剂的中空微囊,24 h体外累积释药量达93.2%。结论悬浮界面交联法能够制备具有壳状结构的PVA中空微囊,可在壳膜层中加入致孔剂,增加物质传输能力。此法制备的微囊具有很好的缓释效果。
Objective To study a new method for preparing shell-like hollow microcapsules and investigate the effect of porogen on the release behavior of microcapsules. Methods Polyethylene glycol (PEG) was added as a pore-forming agent to polyvinyl alcohol (PVA) and hollow shell vesicles with 5-flurourac il (5-FU) were prepared by suspension interfacial crosslinking. Particle size, entrapment efficiency, drug loading optimization prescription process. The effects of porogen on microcapsules release were studied by investigating the in vitro drug release properties. Results The microcapsule prepared by the new process was a shell-like hollow structure with an average particle size of 22 μm and drug loading and encapsulation efficiency of 15.6% and 84.8%, respectively. Hollow microcapsules added porogen, 24 h in vitro cumulative release of 93.2%. Conclusions The suspension interface cross-linking method can prepare PVA hollow microcapsules with shell-like structure, and can add porogen to the shell membrane to increase the material transport ability. The microcapsule prepared by this method has a good sustained-release effect.