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目的探讨补体成分3(C3)与缺血性进展性卒中间的关系。方法对168例发病24 h内续贯住院的脑梗死患者进行前瞻性研究。在入院后第2天或第3天晨抽取静脉血检测血浆C3及其他生化指标,进行单因素及Logistic多元回归分析,了解C3与进展性卒中之间的关系。结果68例患者(40.48%)在住院72 h内病情进展,进展性卒中患者血浆C3水平为(1.28±0.20)g/L,明显高于非进展性卒中患者的(1.16±0.25)g/L(P=0.000);随C3水平的升高,进展性卒中的发生率呈明显升高趋势(P=0.001)。Logistic回归分析显示,C3与进展性卒中呈明显相关(OR=7.247;95%CI=1.52~36.39;P=0.013)。结论C3升高在进展性脑卒中的发病中可能具有重要意义。
Objective To investigate the relationship between complement component 3 (C3) and ischemic stroke. Methods A prospective study of 168 consecutive patients with cerebral infarction within 24 hours of onset of illness was conducted. On the second or third days after admission, venous blood was drawn for plasma C3 and other biochemical parameters, and single factor and Logistic multiple regression analysis were performed to understand the relationship between C3 and progressive stroke. Results 68 patients (40.48%) progressed within 72 hours after hospitalization. The plasma C3 level in patients with progressive stroke was (1.28 ± 0.20) g / L, which was significantly higher than that in patients with non-progressing stroke (1.16 ± 0.25) g / L (P = 0.000). As the level of C3 increased, the incidence of progressive stroke increased significantly (P = 0.001). Logistic regression analysis showed that C3 was significantly associated with progressive stroke (OR = 7.247; 95% CI = 1.52-36.39; P = 0.013). Conclusion The elevated C3 may play an important role in the pathogenesis of stroke.