目的:观察不同剂量辛伐他汀对高脂血症患者的临床疗效及安全性,探讨适合长期服用的有效剂量。方法:对60例高脂血症患者观察1年,其中服用辛伐他汀5mg/d和20mg/d组与未服药的对照组相比。结果:①服药的两组对降低胆固醇(TC)和低密度脂蛋白(LDL-C)有显著性疗效(P<0.01),服辛伐他汀20mg/d的第2组对甘油三脂(TG)可有效降低。②服药的两组与对照组在用药前后查ALT、AST及胆红质、血糖、血尿素氮均无统计学差异。结论:对TC和(或)LDL-C高的患者服用辛伐他汀5mg/d疗效好,对伴TC高的患者服用辛伐他汀20mg/d不仅显著性的降低TC、LDL-C,同时TG有显著性的下降,且剂量增加不导致副作用的增加。 Objective: To observe the clinical efficacy and safety of different doses of simvastatin on patients with hyperlipidemia and to explore the effective dose for long-term use. Methods: Sixty patients with hyperlipemia were observed for one year. Simvastatin 5 mg / d and 20 mg / d were compared with those of the untreated control group. Results: ① The two groups took a significant effect on the reduction of cholesterol (TC) and low density lipoprotein (LDL-C) (P <0.01), the second group of simvastatin 20 mg / ) Can be effectively reduced. ② medication two groups and control group before and after treatment check ALT, AST and bilirubin, blood glucose, blood urea nitrogen were no significant difference. Conclusions: Simvastatin 5 mg / d was effective in patients with high TC and / or LDL-C, and 20 mg / d of simvastatin in patients with high TC did not only significantly reduce TC and LDL-C, but also TG There was a significant decrease, and dose increase did not lead to increased side effects.