论文部分内容阅读
作者报道了在塞内加尔某乙型肝炎高发区的婴儿接种乙型肝炎疫苗后抗体水平持续时间的观察。所有疫苗以甲醛灭活,氢氧化铝为佐剂,含等量ad和ay亚型的纯化HBsAg(5μg/ml);第2次加强免疫用巴斯德疫苗。共接种了156名婴儿(男64人,女92人),平均年龄为11.6月龄。有15人接种前已感染,其中8人HBsAg阳性,7人抗-HBc持续阳性。免疫程序为连续接种3针,间隔时间为1个月,第1针后12个月作第1次加强免疫。于加强免疫时及第2、3、4、5和6年分别采血。56人在5～6年后接受第2次加强免疫,2～3个月后采血。11名婴儿未接受加强免疫,于第1针后7年采血。
The authors report on the duration of antibody levels following hepatitis B vaccine vaccination in infants from a high-risk area of hepatitis B in Senegal. All vaccines were inactivated with formaldehyde, with aluminum hydroxide as adjuvant, and purified HBsAg (5 μg / ml) containing equal amounts of ad and ay subtypes; the second booster vaccine. A total of 156 infants (64 males and 92 females) were vaccinated, with an average age of 11.6 months. Fifteen had been infected before vaccination, of which eight were HBsAg positive and seven were persistent anti-HBc. The immunization procedure consisted of three consecutive injections of an interval of 1 month and the first 12 months after the first injection for the first booster immunization. Blood was collected on the second and third, fourth, fifth and sixth years of booster immunization. Fifty-six people received the second booster immunization after 5 to 6 years and blood was collected after 2 to 3 months. Eleven infants were not boosted, and blood was drawn seven years after the first injection.