论文部分内容阅读
探讨c -fos、c - jun癌基因与肺癌的关系。方法 :采用PT -PCR方法检测肺癌与非恶性肺疾病患者病变组织及正常肺组织中c-fos、c - junmRNA表达。结果 :c -fos、c -junmRNA在两组患者病变组织中的表达均明显高于正常组织 (P <0 .0 0 1) ,在肺癌组织中的表达又高于肺良性肿块组织 (P <0 .0 5 ) ,而且在小细胞肺癌和腺癌组织表达强于鳞癌组织 (P <0 .0 0 1)。结果 :c-fos、c - jun基因过度表达是肺癌发生中的分子事件 ,且与肺癌的病理类型相关 ,但不能作为肺癌的一个诊断指标 ,其表达的强弱仅反映组织细胞增生程度。
To investigate the relationship between c-fos, c-jun oncogene and lung cancer. Methods : The expression of c-fos and c-jun mRNA in lung cancer tissues and normal lung tissues were detected by PT-PCR. RESULTS: The expression of c-fos and c-jun mRNA in the lesions of both groups was significantly higher than that in normal tissues (P < 0.01). The expression of c-fos and c-jun mRNA was higher in lung cancer than in benign lung masses (P < 0. 0 5), but also stronger expression in small cell lung cancer and adenocarcinoma tissues than squamous cell carcinoma tissues (P < 0.01). RESULTS: Overexpression of c-fos and c-jun genes was a molecular event in the development of lung cancer. It was associated with the pathological type of lung cancer, but it could not be used as a diagnostic indicator of lung cancer. The strength of its expression only reflected the degree of tissue cell proliferation.