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目的:探讨葡萄球菌肠毒素瘤体内注射联合放射治疗复发性颈部淋巴结转移癌的临床应用价值。方法:将65例患者随机分为治疗组与对照组。治疗组采用葡萄球菌肠毒素瘤体内注射联合肌肉注射配合放射治疗,对照组仅行放射治疗。两组放射照射剂量均为DT65～70Gy/6.5～7周。结果:治疗结束后治疗组33例患者中,CR15例(45.5%),PR15例(45.5%),RR为90.9%(30/33),NC3例,PD0例。而对照组32例患者中,CR7例(21.9%),PR15例(46.9%),RR为68.8%(22/32),NC10例,PD0例(P<0.05)。治疗结束3个月后复查,结果亦相同。另外对患者的生存质量也有明显的改善作用,P<0.05。结论:葡萄球菌肠毒素瘤体内注射联合肌肉注射,可使颈部转移瘤体内该药物浓度增高,配合放射治疗、增强了其对肿瘤细胞的直接杀伤作用,具有较高的肿瘤消退率、并且改善了患者的生存质量。
Objective: To investigate the clinical value of in vivo injection of staphylococcal enterotoxin combined with radiotherapy for recurrent cervical lymph node metastases. Methods: 65 patients were randomly divided into treatment group and control group. Staphylococcal enterotoxin tumor in vivo injection combined with intramuscular injection of radiation therapy, the control group only radiation therapy. Radiation dose of both groups were DT65 ~ 70Gy / 6.5 ~ 7 weeks. Results: Among the 33 patients in the treatment group, 15 were CR15 (45.5%), PR15 (45.5%), RR was 90.9% (30/33), NC3 and PD0. The control group of 32 patients, CR7 cases (21.9%), PR15 cases (46.9%), RR 68.8% (22/32), NC10 cases, PD0 cases (P lt; 3 months after the end of treatment review, the results are the same. In addition, the quality of life of patients also had a significant improvement, P <0.05. Conclusion: In vivo injection of staphylococcal enterotoxin combined with intramuscular injection can increase the concentration of the drug in the metastatic tumor of the neck. In combination with radiation therapy, the direct killing effect of the drug on the tumor cells is enhanced, and the tumor regression rate is high and improves The patient’s quality of life.