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目的研究大豆异黄酮(SIF)对未成年雌性小鼠卵巢发育的影响。方法将21日龄雌性小鼠进行SIF灌胃染毒(0、50、100和200mg/kg.BW),连续染毒14d,观察体重变化及阴道开放,染毒结束时称量小鼠卵巢,并对卵巢行病理学检查。结果高剂量组卵巢/体重、阴道开放率、发育卵泡数目均>对照组,可见闭锁卵泡、成熟卵泡、多卵卵泡及少量黄体。结论 SIF能影响卵巢的早期发育。
Objective To study the effect of soybean isoflavone (SIF) on ovarian development in female mice. Methods 21-day-old female mice were orally administered with SIF (0, 50, 100 and 200 mg / kg.BW) for 14 days. Body weight changes and vaginal opening were observed. At the end of the treatment, And pathological examination of the ovary. Results The ovarian / body weight, vaginal opening rate and the number of developing follicles in the high-dose group were all higher than those in the control group. Atresia follicles, mature follicles, multiple follicles and a small amount of corpus luteum were observed. Conclusion SIF can affect the early development of ovary.