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目的:分析鼻咽癌CT征象与nm23蛋白表达关系来推测其生物学特性。方法:患者行CT扫描,免疫组化方法检测肿瘤细胞nm23蛋白表达。结果:鼻咽腔多或单侧壁肿块组与有或无颈部淋巴结转移组,nm23蛋白表达差异有统计学意义;有或无茎突旁软组织肿块组与有或无侵及后鼻孔组,nm23蛋白表达差异无统计学意义。结论:鼻咽腔多侧壁肿块、颈部淋巴结转移与nm23蛋白降低有关,显示肿瘤易发生转移。
OBJECTIVE: To analyze the relationship between CT features of nasopharyngeal carcinoma and the expression of nm23 protein to speculate its biological characteristics. Methods: The patients underwent CT scan and immunohistochemistry to detect the expression of nm23 protein in tumor cells. Results: The expression of nm23 protein in nasopharyngeal multi - or single - sided wall mass group with or without cervical lymph node metastasis was significantly different; with or without paravertebral soft tissue mass group with or without invasion and posterior nares group, nm23 protein expression difference was not statistically significant. Conclusion: Multiple nasopharyngeal wall masses and cervical lymph node metastasis are associated with the decrease of nm23 protein, which indicates the tumor is prone to metastasis.