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目的:观察中药清热利湿通络加减方在幼年类风湿关节炎关节疼痛的临床效果。方法:选取60例幼年类风湿关节炎患者,随机分为对照组28例,试验组32例,对照组采用来氟米特与甲氨蝶呤联合治疗,试验组采用中药清热利湿通络加减方治疗,以3个月为一疗程,观察2个疗程后的临床效果。结果:试验组有效率(93.7%),对照组(82.1%),差异有统计学意义(P<0.05);两组患儿在关节功能评分、关节压痛指数、肿胀指数、晨僵时间及血检验指标均较治疗前有显著改善(P<0.01),且试验组的疗效优于对照组,差异有统计学意义(P<0.05)。结论:中药清热利湿通络方能够缓解幼年类风湿关节炎的关节肿胀、疼痛,改善关节功能,疗效显著,不良反应小,值得临床推广。
Objective: To observe the clinical effect of clearing heat, dampness and dampness and dampness collaterals prescriptions on joint pain in juvenile rheumatoid arthritis. Methods: Sixty cases of juvenile rheumatoid arthritis were selected and randomly divided into control group (n = 28) and experimental group (n = 32). The control group was treated with leflunomide combined with methotrexate. The experimental group was treated with traditional Chinese medicine Reduction treatment, to 3 months for a course of treatment, observe the clinical effect of 2 courses. Results: The effective rate was 93.7% in the test group and 82.1% in the control group (P <0.05). The scores of joint function, joint tenderness index, swelling index, morning stiffness and blood in the two groups were significantly different The test indexes were significantly improved compared with that before treatment (P <0.01), and the curative effect of the experimental group was better than that of the control group (P <0.05). Conclusion: The traditional Chinese medicine Qingre Lishi Tongluo Recipe can relieve the swelling and pain of joint in juvenile rheumatoid arthritis and improve the joint function. The curative effect is obvious and the adverse reaction is small, which is worthy of clinical promotion.