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目的观察异甘草酸镁(天晴甘美)与甘欣联合还原型谷胱甘肽治疗化疗药物所致肝损害的疗效。方法采用随机对照研究,设立治疗组与对照组,治疗组24例,给予天晴甘美0.2 g加10%葡萄糖注射液250mL,每天静脉滴注1次,还原型谷胱甘肽(古拉定)1 800 mg加5%葡萄糖注射液250 mL,每天静脉滴注1次,疗程10 d。结果治疗结束,治疗组与对照组比较,治疗组ALT有95.83%(23/24)恢复正常,而对照组只有69.23%(18/26),治疗组AST有90.48%(19/21)恢复正常,而对照组只有63.64%(14/22),治疗组Tbil恢复正常仅6例,占60.0%(6/10);对照组Tbil恢复正常7例,占53.85%(7/13),2组比较差异无统计学意义(P>0.05);2组未出现严重的不良反应,不影响治疗。结论天晴甘美联合还原型谷胱甘肽治疗化疗药物性肝损害降低谷丙转氨酶、谷草转氨酶疗效显著,不良反应少,值得临床推广。
Objective To observe the effects of magnesium isoglycyrrhizinate (Ganoderma lucidum) and Ganxin combined with reduced glutathione (GSHG) in the treatment of liver injury caused by chemotherapy drugs. Methods A randomized controlled study was conducted to establish a treatment group and a control group. 24 cases in the treatment group were given 250 ml of sweet loquat 0.2 g plus 10% glucose injection once a day, and reduced glutathione (Gladatin) 1 800 mg plus 5% glucose injection 250 mL intravenously once daily for 10 days. Results After treatment, 95.83% (23/24) of ALT in treatment group returned to normal compared with that of control group, while only 69.23% (18/26) in control group and 90.48% (19/21) in treatment group returned to normal Compared with 63.64% (14/22) in the control group and 6 cases (60.0%) in the treatment group (6/10). The control group returned to normal in 7 cases (53.85%, 7/13) The difference was not statistically significant (P> 0.05); 2 groups did not appear serious adverse reactions, does not affect the treatment. Conclusions Clear sweet combined with reduced glutathione treatment of chemotherapy-induced liver injury reduce alanine aminotransferase, aspartate aminotransferase significant effect, fewer adverse reactions, is worth clinical promotion.