论文部分内容阅读
The depressant-like effects of albiflorin(AF)were studied on stressed chronic restraint stress(CRS)rats.Experimental rats were subjected to immobilization stress for a daily 6 h-restraining in a plastic restrainer for continuous 21 d and were treated with 30 or 15 mg-kg-1of AF for 21 d.Control rats were maintained in completely non stressed conditions.Behavioral tests and biochemical analysis were applied to investigating a regulatory mechanism of anti-stress of AF.Treatment with AF significantly restored the de-pressant-like behaviors.Besides,AF increased the levels of 5-hydroxytryptophan(5-HT),5-hydroxyindoleacetic acid(5-HIAA),noradrenaline(NE)and dopamine(DA)in the hippocampus and increased the level of brain-derived neurotrophic factor(BDNF)in serum and protein expression in hippocampus.In addition,AF decreased the levels of hypothalamo-pituitary-adrenal(HPA)cascade,reduced the level of NO and cGMP in serum and inhibited the overexpression of 5-HT2AR mRNA and protein expression.Taken to-gether,AF can modulate the NO-mediated network pathway in the hippocampus against stress-induced depressive-like behaviors.These physiological and behavioral changes allow rats to avoid potential deleterious effects of stress that may result from chronically elevated levels of glucocorticosteroids over days.