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目的探讨运动与白藜芦醇对老年肥胖大鼠内脏脂肪抵抗素表达及血浆抵抗素浓度的影响。方法清洁级雄性21日龄SD幼鼠分生长发育期、壮年期和老年期三个阶段增肥,建立老年肥胖大鼠模型,选取6只自然生长老年大鼠为空白对照组(C),选取24只肥胖老年大鼠为实验组,随机分为4组,每组6只,分别为肥胖对照组(OC),补充白藜芦醇组(OR),运动组(OE),运动结合白藜芦醇组(OER)。动物跑台速度及时间为每组15 m/min×15 min,4组/次,组间休息5 min,60 min/次;白藜芦醇灌胃52.5 mg/kg,1次/d;5次/周,连续8周。测血糖、血胰岛素,计算胰岛素抵抗,检测内脏脂肪组织抵抗素mRNA表达及血浆抵抗素浓度。结果 OC组的体重、内脏脂肪重量和体脂率、血糖、胰岛素抵抗均高于C组(P<0.01,P<0.05),内脏脂肪组织抵抗素mRNA表达×10~3(29.80±4.91)和血浆抵抗素浓度[(4.30±1.93)μg/L]高于C组[分别为(23.09±6.12)和(3.49±0.42)μg/L],但差异无统计学意义。OE、OER组体重、内脏脂肪重量和体脂率、血糖、胰岛素抵抗低于OC组(P<0.01,P<0.05),OR组低于OC组,OER组低于OE组,但差异无统计学意义。OR组内脏脂肪组织抵抗素mRNA表达(×10~3)(21.63±4.91)低于OC组(P<0.05),OE、OER组[分别为(28.21±4.80)、(25.22±11.12)]低于OC组,但差异无统计学意义。OR、OE和OER组血浆抵抗素浓度[分别为(3.71±1.01)、(3.29±1.19)和(2.99±0.44)μg/L]低于OC组,OER组低于OE组,OE组低于OR组,但差异无统计学意义。结论老年肥胖伴随胰岛素抵抗和高血糖,内脏脂肪抵抗素表达及血浆抵抗素浓度偏高;单纯运动及运动结合白藜芦醇明显降低老年肥胖大鼠的体重、内脏脂肪重量、体脂率、血糖和胰岛素抵抗,但对内脏脂肪抵抗素表达及血浆抵抗素浓度影响较小,单纯补充白藜芦醇能降低内脏脂肪组织抵抗素mRNA表达。
Objective To investigate the effects of exercise and resveratrol on expression of visceral fat resistin and plasma resistin in aged obese rats. Methods Clean male SD rats aged 21 days were divided into three stages: growth and development, maternal and senile stages to establish an aged obese rat model. Six naive, aged rats were selected as control group (C) Twenty-four obese aged rats were randomly divided into 4 groups (6 rats in each group): obese control group (OC), resveratrol group (OR), exercise group (OE) Aldol group (OER). The speed and time of animal treadmill were 15 m / min × 15 min in each group, 4 groups / time, 5 min, 60 min / time in each group. Resveratrol was administered intragastrically at 52.5 mg / kg once daily Times / week for 8 weeks. Blood glucose and blood insulin were measured, insulin resistance was calculated, mRNA expression of visceral adipose tissue resistin and plasma resistin concentration were measured. Results Body weight, visceral fat mass, body fat percentage, blood glucose and insulin resistance in OC group were significantly higher than those in C group (P <0.01, P <0.05), resistin mRNA expression in visceral adipose tissue ranged from 10 to 3 (29.80 ± 4.91) Plasma resistin concentration was significantly higher than that of C group [(4.30 ± 1.93) μg / L [23.09 ± 6.12 vs (3.49 ± 0.42) μg / L, respectively], but the difference was not statistically significant. The body weight, visceral fat mass, body fat percentage, blood glucose and insulin resistance in OE and OER groups were lower than those in OC group (P <0.01, P <0.05) Significance of learning. The mRNA expression of resistin in visceral adipose tissue in OR group was lower than that in OC group (× 10 ~ 3) (21.63 ± 4.91) (P <0.05), while it was lower in OE and OER groups (28.21 ± 4.80 and 25.22 ± 11.12 respectively) In OC group, but the difference was not statistically significant. Plasma resistin concentrations in OR, OE and OER groups were significantly lower than those in OC group [(3.71 ± 1.01), (3.29 ± 1.19) and (2.99 ± 0.44) μg / L, respectively) OR group, but the difference was not statistically significant. Conclusion Elderly obesity accompanied with insulin resistance and hyperglycemia, visceral fat resistin expression and plasma resistin concentration were higher; exercise alone and exercise combined with resveratrol significantly reduced body weight, visceral fat mass, body fat percentage, blood glucose And insulin resistance, but had little effect on visceral adiponectin expression and plasma resistin concentration. Simply adding resveratrol could reduce visceral adipose tissue resistin mRNA expression.