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探讨生长抑素（ＳＳ）和Ｐ物质（ＳＰ）在大鼠胃电节律失常中的作用。利用大鼠胃电节律失常模型，测量胃窦肌间神经丛中生长抑素免疫反应（ＳＳ－ＩＲ）神经和Ｐ物质免疫反应（ＳＰ－ＩＲ）神经的含量。分别记录注射ＳＳ类似物善得定（奥曲肽，Ｏｃｔ）和ＳＰ后的胃电活动。与对照组比较，实验组大鼠胃窦肌间神经丛ＳＳ－ＩＲ神经含量明显增多，而 ＳＰ－ＩＲ神经含量明显减少（ Ｐ＜０． ０５）。注射Ｏｃｔ后出现胃电节律失常，注射ＳＰ后胃电节律无明显变化，只是快波（ｆａｓｔ ｗａｖｅ）的发放明显增多。表明胃窦肌间神经丛中ＳＰ－ＩＲ神经与ＳＰ－ＩＲ神经的比例失调可能是胃电节律失常发生的重要原因之一。
To investigate the role of somatostatin (SS) and substance P (SP) in gastric antrum dysregulation in rats. The content of somatostatin-immunoreactive (SS-IR) nerve and substance-P immunoreactivity (SP-IR) nerves in gastric antrum myenteric plexus were measured using rat model of gastric electrogastric dysrhythmia. Gastric activity was recorded after injection of SS analogs, sertraline (Octreotide, Oct) and SP, respectively. Compared with the control group, the content of SS-IR in gastric myenteric plexus in the experimental group increased significantly, while the content of SP-IR nerve decreased significantly (P <0.05). Gastric electrical arrhythmia was found after injection of Oct, there was no significant change of gastric electrical rhythm after injection of SP, but the release of fast wave increased obviously. It is suggested that the imbalance between the SP-IR nerve and the SP-IR nerve in the myenteric plexus may be one of the important causes of gastric electrical arrhythmia.