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本文就国产DHAQ对小鼠和兔的急性毒性和小鼠移植性肿瘤的实验治疗进行了研究并与同类药阿霉素作了比较。结果测得小鼠一次静脉及腹腔注射本品观察21天的LD_(50)分别为6.58及6.48mg/kg与同期所测阿霉素的LD_(50)值相近而略低,二药在剂量范围为5—25mg/kg时引起动物死亡的最早日期为给药后3天,直到21天仍有个别动物陆续死亡,显示毒性的延
In this paper, the acute toxicity of domestic DHAQ on mice and rabbits and experimental treatment of mice transplanted tumors were studied and compared with similar drugs doxorubicin. Results The LD_ (50) of 21 days after intravenous and intraperitoneal injection in mice was 6.58 and 6.48 mg / kg, respectively, which was slightly lower than the LD_ (50) value of adriamycin measured in the same period. The earliest date of death that caused the animal in the range of 5-25 mg / kg was 3 days after dosing, and until 21 days some animals died one after another, indicating prolonged toxicity