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目的 观察磺脲类合并二甲双胍继发失效的２ 型糖尿病加用拜糖平的疗效。方法 将５０ 例磺脲类与双胍类联合治疗继发失效的２ 型糖尿病人按非等量随机分组的原则分为拜糖平组（３０例） 和安慰剂组（２０ 例） ，治疗３ 个月，比较治疗。结果 拜糖平组患者的空腹和餐后１ 、２ 小时血糖明显下降，有效率为４８ ．３ ％ ；安慰剂组治疗前后血糖维持不变，仅１ 例有效。结论 加用拜糖平可作为磺脲类与双胍类药物联合应用失效后的治疗方法之一。
Objective To observe the curative effect of sulfonylurea combined with metformin secondary failure of type 2 diabetes mellitus plus cyproterone. Methods Fifty patients with type 2 diabetes who were treated with sulfonylureas and biguanides were divided into two groups according to the principle of non-equal randomization: orallysone (30 cases) and placebo (n = 20) Month, more treatment. Results The patients on the fasting and postprandial 1, 2 hours postprandial blood glucose significantly decreased, the effective rate was 48. 3%; placebo group before and after treatment, blood glucose remained unchanged, only 1 case effective. Conclusions The use of cyproterone can be used as a combination of sulfonylurea and biguanide drugs after failure of one of the treatment methods.