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目的 :研究非胰岛素依赖型糖尿病 (NIDDM)大鼠心肌组织葡萄糖转运体 4(glucose transporter4,GL UT4) m RNA表达变化。方法 :制备 NIDDM大鼠模型 ,用 Northern blotting方法测定心肌组织中 GL UT4m RNA表达量。结果 :NIDDM大鼠心肌组织 GL UT4m RNA表达显著低下 ,仅为对照组的 5 4% (P<0 .0 1)。结论 :NIDDM大鼠心肌 GL UT4m RNA表达量低下 ,该反应与 NIDDM大鼠体内胰岛素分泌总体水平低下有关。
Objective: To investigate the mRNA expression of glucose transporter 4 (GLUT4) in myocardium of non-insulin dependent diabetic (NIDDM) rats. Methods: NIDDM rat model was prepared, and the amount of GLUT4m RNA in myocardium was determined by Northern blotting. Results: The expression of GLUT4m RNA in myocardium of NIDDM rats was significantly lower than that of the control group (54%, P <0.01). CONCLUSION: The low level of GLUT4m RNA in myocardium of NIDDM rats is related to the low overall level of insulin secretion in NIDDM rats.