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目的比较观察阿托伐他汀与辛伐他汀联合阿司匹林治疗颈动脉粥样硬化的疗效。方法选择我院106例伴有颈动脉粥样硬化的患者,随机分为A.B两组.A组服用阿托伐他汀10mg联合阿司匹林75mg.B组服用辛伐他汀10mg联合阿司匹林75mg.均每日一次,疗程6个月.治疗前后彩色多普勒超声检测颈动脉内膜-中层的厚度及斑块大小。结果服药6个月后与治疗前相比,两组的颈动脉内膜-中层厚度及斑块大小治疗后明显缩小(P<0.05),但以A组更明显。结论阿托伐他汀.辛伐他汀联合阿司匹林均可明显减轻颈动脉粥样硬化病变,但阿托伐他汀联合阿司匹林的疗效更为显著.
Objective To compare the effects of atorvastatin and simvastatin combined with aspirin in the treatment of carotid atherosclerosis. Methods One hundred and six patients with carotid atherosclerosis in our hospital were randomly divided into two groups: A group took atorvastatin 10mg combined with aspirin 75mg.B group took simvastatin 10mg combined with aspirin 75mg once daily , Course of treatment was 6 months.The thickness and plaque size of carotid intima-mediastinum were detected by color Doppler sonography before and after treatment. Results Compared with before treatment, carotid artery intima-media thickness and plaque size in both groups were significantly reduced (P <0.05) after 6 months of treatment, but were more obvious in group A than those before treatment. Conclusions Both atorvastatin, simvastatin and aspirin can significantly reduce the carotid atherosclerosis, but the combination of atorvastatin and aspirin is more effective.