论文部分内容阅读
目的:检测乳腺癌组织中N-乙酰氨基葡萄糖转移酶Ⅴ(GnT-Ⅴ)的活性并分析其临床意义。方法:应用组织芯片技术构建12×10乳腺癌组织阵列块,通过凝集素印迹法检测以白细胞植物凝集素(PHA-L)标记的GnT-Ⅴ在57例乳腺癌和12例乳腺良性病变中的活性,并探讨其与临床病理学参数间的关系。结果:乳腺癌组织中PHA-L阳性89.47%(51/57),胞质阳性,乳腺良性病变组织中PHA-L阳性8.33%(1/12),两者存在显著性差异(P<0.01)。乳腺癌中GnT-Ⅴ活性在不同病理类型、不同淋巴结转移状况、不同病理分期患者中的表达无明显差异。结论:乳腺病灶GnT-Ⅴ高活性提示病变恶性可能大,可以GnT-Ⅴ为靶点,治疗出现复发及转移三阴的乳腺癌患者。
Objective: To detect the activity of N-acetylglucosaminyltransferase Ⅴ (GnT-Ⅴ) in breast cancer tissues and analyze its clinical significance. Methods: Tissue microarray was used to construct arrays of 12 × 10 breast cancer tissue. The lectin-labeled GnT-Ⅴ was detected by lectin blotting in 57 cases of breast cancer and 12 cases of benign breast lesions Activity, and to explore its relationship with clinicopathological parameters. Results: The PHA-L positive rate in breast cancer was 89.47% (51/57), positive in cytoplasm, and 8.33% (1/12) in PHA-L in benign breast lesions. There was significant difference between the two (P <0.01) . GnT-Ⅴ activity in breast cancer in different pathological types, different lymph node metastasis, different pathological stages of patients showed no significant difference. Conclusion: The high GnT-Ⅴ activity in breast lesions suggests that the malignant lesions may be large. GnT-Ⅴ can be used as a target for the treatment of breast cancer patients with recurrent and metastatic Sanyin.