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一、自由基与冠脉血管反应临床上已经明确,没有再通的心肌梗死属于缺血性梗死,与此相反,再通的梗死区内有多量的出血。病理组织学发现,梗死区内有毛细血管、小静脉或静脉窦破裂、出血,而动脉系统的出血则很少。实验证明,黄嘌呤—黄嘌呤氧化酶反应可以引起猫肠系膜微循环系统的毛细血管后小静脉与小静脉(20μm以上)的分枝部发生点状出血。假如此过程中伴随再灌流生成了自由基,则自由基就成为促进出血性梗死的一个因子。与这种组织学变化相对应,Ku于1982年发
First, the free radical and coronary vascular response has been clinically clear, no recanalization of myocardial infarction is ischemic infarction, on the contrary, recanalization of the infarct area, there is a large amount of bleeding. Histopathology found that there are capillaries in the infarct area, venules or venous sinus rupture, bleeding, arterial system bleeding is very small. Experiments show that xanthine - xanthine oxidase reaction can cause cat intestinal mesenteric microcirculation system after the small venules and venules (20μm above) branch occurred punctate bleeding. If free radicals are formed during this process with reperfusion, then free radicals become a factor in promoting hemorrhagic infarction. Corresponding to this histological change, Ku was published in 1982