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目的探讨血浆氨基末端脑钠肽原(NT-proBNP)及血清糖类抗原125(CA125)对先天性心脏病(CHD)患儿心功能评价及心力衰竭(心衰)早期诊断的临床应用价值。方法 74例CHD患儿分为CHD心衰组(A组,34例)和CHD无心衰组(B组,40例),22例门诊健康体检儿童作为对照组(C组),应用ELISA法测定血浆NT-proBNP和血清CA125浓度。结果A组血浆NT-pro-BNP浓度高于B、C组(P<0.01);A组患儿血浆NT-proBNP浓度随心衰程度的加重而升高(P<0.01)。A组患儿血清CA125浓度高于C组(P<0.01)。CHD患儿血浆NT-proBNP和血清CA125浓度分别均与改良ROSS评分呈正相关(r=0.941和r=0.690,P<0.01)。结论 CHD患儿合并心衰时血浆NT-proBNP及血清CA125浓度升高,可用于CHD患儿的心功能评价及心衰的早期诊断。
Objective To investigate the clinical value of plasma NT-proBNP and serum carbohydrate antigen 125 (CA125) in the evaluation of cardiac function and early diagnosis of heart failure (CHF) in children with congenital heart disease (CHD). Methods 74 children with CHD were divided into three groups: CHD group (34 cases), CHD group (40 cases), and 22 healthy children (control group) Plasma NT-proBNP and serum CA125 concentrations were determined. Results The plasma concentration of NT-pro-BNP in group A was higher than that in group B and C (P <0.01). The plasma concentration of NT-proBNP in group A was increased with the severity of heart failure (P <0.01). The serum concentration of CA125 in group A was higher than that in group C (P <0.01). The plasma concentrations of NT-proBNP and serum CA125 in children with CHD were positively correlated with the improved ROSS score (r = 0.941 and r = 0.690, P <0.01). Conclusion The plasma NT-proBNP and serum CA125 levels in children with CHD complicated by heart failure are elevated, which can be used for the evaluation of cardiac function and the early diagnosis of heart failure in children with CHD.