泌尿道上皮长期受物理刺激、慢性炎症可能发生化生性鳞癌,在长期结石、使用导管、炎症时,应考虑到潜伏癌肿的可能。本文报告的4例中,3例有慢性尿路感染,且时间在20年以上,系尿道上皮化生的一个因素,应尽早诊断,及时治疗。瘫痪病人长期使用的导管,以硅胶管为好。 Long-term urinary tract by the physical stimulation, chronic inflammation may occur metaplastic squamous cell carcinoma, in the long-term stones, the use of catheters, inflammation, should consider the possibility of latent cancer. Among the 4 cases reported in this paper, 3 cases had chronic urinary tract infection and the time was more than 20 years. It was a factor of urethral metaplasia that should be diagnosed and treated as soon as possible. Long-term use of paralyzed patients catheter, silicone tube as well.