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为探讨补益脾肾、化瘀攻坚的中药制剂脑瘤康平煎剂与卡氮芥 (BCNU)联合治疗G4 2 2脑胶质瘤的作用机理 ,应用单克隆抗体免疫荧光及激光偏振技术 ,观察发现脑瘤康平煎剂能促进荷瘤小鼠胸腺及脾脏的增生 ,且能改变BCNU对免疫器官功能的抑制 ;调整T细胞亚群的比值失调 (中药组为 1.35± 0 .2 5,对照组为 0 .95± 0 .0 9,两组比P <0 .0 1) ;在调整脑内单胺类神经递质 5-羟色胺 (5-HT)水平方面 ,中药组为 (391.4± 57.8)ng/g ,对照组为 (582 .4± 35.0 )ng/g,两组比较P <0 .0 1。提示 :中药脑瘤康平煎剂调节免疫功能的机理可能是通过神经内分泌网络起作用
In order to explore the mechanism of G4-2 2 glioma treatment by combining traditional Chinese medicine Naolumikang decoction with BCNU, which is a traditional Chinese medicine preparation for invigorating the spleen and kidney and removing blood stasis and stasis, monoclonal antibody immunofluorescence and laser polarization are used to observe the mechanism Brain tumor Kang-ping decoction can promote tumor-bearing mouse thymus and spleen proliferation, and can change the inhibition of immune function of BCNU; adjust the ratio of T cell subsets imbalance (Chinese medicine group was 1.35 ± 0.25, the control group was 0. 95 ± 0. 0 9, P <0.01). In terms of adjusting the levels of monoamine neurotransmitter 5-HT in the brain, the Chinese medicine group was (391.4 ± 57.8) ng / g in the control group and (582 ± 35.0) ng / g in the control group, P <0.01. Tip: Chinese medicine brain tumor Kang-ping decoction mechanism may regulate immune function through the role of neuroendocrine network