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目的 探索早期乳腺癌保留乳房治疗的新途径。方法 1995 - 1997年采用术前动脉插管化疗加乳腺区段切除治疗Ⅰ、Ⅱ期乳腺癌共 2 6例 ,并随访 5年以上。结果 2 6例中 1例术后 2年 4个月死于肺转移 ,另 1例术后 4年死于其他疾病。 1例术后 1年复发 ,行全乳房切除后至今无瘤生存 6年。本组 3年生存率 (OS) 96 .15 % ,3年无瘤生存率 (DFS) 92 .3% ;5年OS 88.4 6 % ,5年DFS 88.4 6 %。结论 术前动脉插管化疗能提高肿瘤区域的药物浓度 ,杀灭部分癌细胞 ,减少术后复发。该疗法对部分Ⅰ、Ⅱ期乳腺癌病例是可行的。
Objective To explore a new way to preserve breast cancer in early breast cancer. Methods Between 1995 and 1997, 26 cases of stage Ⅰ and Ⅱ breast cancer were treated with preoperative arterial catheterization and resection of breast segment, followed up for more than 5 years. Results Of the 26 cases, 1 died of lung metastases 2 years and 4 months after operation, and the other died of other diseases 4 years after operation. One case had recurrence one year after operation, and survived 6 years without tumor after total mastectomy. The three-year survival rate (OS) 96.15%, 3-year disease-free survival (DFS) 92.3%, 5-year OS 88.4 6% and 5-year DFS 88.4 6%. Conclusion Arterial intubation chemotherapy can increase the drug concentration in the tumor area, kill some cancer cells and reduce the recurrence after operation. The treatment of some Ⅰ, Ⅱ breast cancer cases are feasible.